MILDURA residents can have up to five adults in their home plus their dependents as COVID restrictions eased across regional Victoria on Friday.

Victoria has recorded one new locally acquired coronavirus case as restrictions also eased for Melbourne residents.

The Department of Health on Friday confirmed just one new local COVID-19 infection from a primary close contact of an existing case.

Another case involves a returned traveller in hotel quarantine. The total number of active cases in the state remains at 54.

Some 35,252 Victorians were tested in the 24 hours to midnight on Thursday while 16,710 received a COVID-19 vaccine dose at state-run hubs.

It comes as Melburnians are no longer subject to the 25km travel limit and can enter regional Victoria for the first time in three weeks after the state's fourth COVID-19 lockdown.

Under the latest raft of rule changes from 11.59pm on Thursday, people in Melbourne can host two adult visitors into their homes per day and gather outdoors in groups of 20.

Masks are not required outdoors anymore, although they must be carried at all times and worn when social distancing is not possible.

Businesses such as gyms and indoor entertainment venues can reopen, while density limits at offices, cafes, restaurants and pubs have increased.

In regional Victoria, 50 people can gather outdoors, while outdoor community sport will allow for 1000 people.

A full list of restrictions can be found at www.coronavirus.vic.gov.au.